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Atherosclerosis and coronary heart disease Studies have shown that 5-Aza-dC (decitabine) treatment of Ldlr/ mice can inhibit the migration and adhesion of macrophages to epithelial cells, reduce the infiltration of macrophages into atherosclerotic plaques and the expression of inflammatory genes in macrophages, 216 thus alleviating atherosclerotic lesions and reducing the development of atherosclerosis