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Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages

R., Marcus, R

The pathophysiology of acute pancreatitis-associated lung injury in humans begins with an impaired pancreas and the subsequent release of digestive enzymes into the systemic circulation, such as phospholipase A 2 , elastase, and trypsin, which further induces endothelial breakage and vascular permeability in the lungs [80]