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Cell 186 (13), 27482764.e22

HBV breakpoints resulting in HBV-DNA integration most commonly localize within a 1,800 bp region of the HBV genome, preserving the structural integrity of the envelope, X and polymerase open reading frames [4]

(3) robust target deconvolution and mechanism-of-action studies across key pathways (e.g., NF-B, AMPK, PI3K/AKT/mTOR, sirtuins) to guide rational medicinal chemistry and biomarker selection