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Purpose-built for physicians Generational decline in testosterone levels observed Trend does not seem to be attributable to health and lifestyle changes

See GL, Arce F Jr, Dahlizar S, Okada A, Fadli M, Hijikuro I, et al

Mutations in these genes result in impaired mitophagy and inflammatory responses, leading to the accumulation of abnormally aggregated proteins, exacerbating neuronal damage, and causing peripheral neuropathy and autonomic dysfunction

Among the most important are the degeneration of dopaminergic neurons and the loss of the substantia nigra, combined with the intracellular aggregation of -synuclein, which forms Lewy bodies and neurites [7]