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A 2016 meta analysis evaluating the impact of cigarette smoking on semen quality demonstrated a clear negative effect of tobacco exposure on male fertility. Synthesizing results from 20 studies and 5,865 men, the Effects of marijuana and tobacco on male fertility and their relationship to genetic variation of mitochondrial cytochrome C oxidase genes Scientific Reports Chewing Tobacco It Isn't Safer 4 Seasons Dental Adverse Effects of Nicotine on Human Sperm Nuclear Proteins PMC
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