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Looking at this tablet of vitamin B12 foods that are vegan, it is certainly possible to meet B12 requirements as a vegan without the need of a supplement

Biomedicine & Pharmacotherapy, 62(4), 236-249

On the other hand, the presence of the GIY-YIG domain reduces the ability of GRXS16 to suppress the susceptibility of yeast grx5 mutant to oxidative stress