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When MDSCs lacking PLC2 were transferred into wild-type mice, the result was increased tumor progression, underscoring the enzymes critical role in MDSC regulation

B.RamachandranA.et al (2006)

Introduction Nitric oxide synthase (NOS) exhibits two alternative activities depending on the relative availability of its cofactor tetrahydrobiopterin (BH4) ( Figure 1 ) In the presence of sufficient BH4, NOS catalyzes the production of NO and citrulline from the amino acid arginine