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Reduce susceptibility to cefiderocol in gram-negative bacteria in children: is hope already lost before it's even arrived

In previous work, we showed that the target of rapamycin (TOR) pathway is a critical mediator of CO 2 tolerance and that, in part, this was due to the role of TOR in remodeling of phospholipid asymmetry of the plasma membrane in response to host CO 2 [12]