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In an autologous blood injection model of ICH, PDZ improves neurological recovery, an effect blocked by the Nrf2 inhibitor ML385, demonstrating that PPAR/Nrf2/GPX4 signaling underlies its protective mechanism (197)

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an antibody of the invention e.g., a heavy or light chain of an antibody of the invention or a portion thereof or a single chain antibody of the invention an expression vector containing a polynucleotide that encodes the antibody Once a polynucleotide encoding an antibody or a heavy or light chain of an antibody, or portion thereof (preferably, but not necessarily, containing the heavy or light chain variable domain), of the invention has been obtained, the vector for the production of the antibody may be produced by recombinant DNA technology using techniques well known in the art