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In cardiac cells, UQCRC1 prevents ischemia/reperfusion injury by activating the PI3K/Akt/GSK-3 pathway, upregulating the anti-apoptotic protein Bcl-2, and downregulating the pro-apoptotic protein Bax (Yi et al., 2020)

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In a mouse model of myocardial infarction, directly transplanted exogenous mitochondria derived from mesenchymal stem cells were better at protecting cardiac function than mitochondria derived from skin fibroblasts