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Using these enzyme preparations with a defined GSH concentration (20 M) in the established two-step in vitro reactions, we found that the extent of conversion of the ultrafiltered flavan-3,3,4-triol ( 4 ) depended on the applied concentration of the purified Pt GSTF8, confirming that this enzyme is required and sufficient for the observed conversion to cyanidin (Extended Data Fig

NADPH, a major cellular reductant, supports the enzymatic activity of FSP1, which resides on the plasma and outer mitochondrial membranes

Inhibiting NF-B, a crucial transcription factor that controls the pro-inflammatory response, activated the Nrf2 signaling pathway

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