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Figure 7 diagrams how such interventions have been applied in different organs (heart, brain, kidney) and what outcomes have been observed or expected, bridging mechanism to clinical translation

It is conceivable that multiple cysteines in Keap1 can be modified by different inducers and it is likely that sites of sulfhydryl modification may vary among the different chemical compound classes and across species [118]

Shi Y, Massagu J

Cependant, chez les consommateurs chroniques dalcool, la production de NAPQI peut augmenter, car le foie fabrique de plus grandes quantits de lenzyme CYP2E1, qui transforme le paractamol en mtabolite toxique