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Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

Chronic stress elevates cortisol, which promotes fat storage particularly in abdominal areas, exactly where many people want to lose fat

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In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation