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The NEJM June 2026 randomized controlled trial enrolled 1,000 adults with septic shock across Australia and New Zealand Two Hours of Sleep Only Restored One of Four Cognitive Domains

the mechanisms exploited involve interventions on the RAS system [angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs)], vasodilation induced by direct vasodilators [calcium channel blockers (CCBs) such as dihydropyridine], the reduction in atrioventricular conduction (beta-blockers, CCBs such as phenylalkylamine, benzothiazepine), or diuretic actions capable of reducing electrolyte levels, particularly Na + (including loop diuretics, thiazides, and potassium sparing)

Guo F et al

Our findings indicate that control adult rats demonstrated improved learning and memory after caffeine and paraxanthine administration, which may suggest a heightened stress level among these animals