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Why injectable plus topical produces a different result than topical alone GHK-Cu applied topically to intact skin has limited dermal penetration

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Start slowly, use an appropriate concentration, choose a delivery vehicle that works with your skin barrier rather than against it, and be thoughtful about how you layer GHK-Cu with pH-sensitive actives like vitamin C and cell-turnover accelerators like retinol

(4) Fangru Jiang, Yanan Wu, Zhe Liu, et al (2023) Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests Journal of Cosmetic Dermatology, 2023 Sep, Volume 22 (Issue 9), Pages 2598-2604