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Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease

Participants with 1% Ki-67 expression as scored on immunohistochemistry by central pathology review at the Department of Pathology of LUMC, were randomized between standard neoadjuvant chemotherapy or received neoadjuvant letrozole at 2.5 mg daily plus intermitted treatment with ribociclib (600 mg per day on days 121 of a 4-week cycle for 20 weeks for five cycles) followed by surgery

The lower matrix metalloproteinase activities resulted in less collagen degradation

A P value less than.05 was considered statistically significant