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The hippocampus serves as a critical region of interest in this study for two key reasons: once the aforementioned ghrelin-mediated influence on hippocampal neurogenesis and synaptic plasticity, and the established role of the hippocampus in the pathophysiology of major depression 40 , highlighting its relevance to obesity-depression comorbidity

This approach emerged pragmatically from research schedules but aligns well with receptor recovery kinetics and avoids the potential tolerance development that continuous daily dosing over many weeks might produce

A meta-analysis revealed that, compared with the GLP-1R agonists, placebo, and insulin, tirzepatide significantly reduced body mass index, waist circumference, and body weight [75]

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