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Anderson ME, Nilsson M, Sims NR

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Cancer cells produce more spatially concentrated ROS than normal cells, which hyperactivates the cell signaling pathways required for cellular transformation and carcinogenesis (Figure 2)

Interestingly, higher lactate levels are frequently observed in patients with milder cognitive impairment, indicating a potential compensatory metabolic change or a shift resembling the Warburg effect in the early stages of neurodegeneration