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doi: 10.3390/molecules21121694 481 Delgado-RocheLGonzlezKMestaFCouderBTavarezZZavalaRet al

27, 29 TxNIP can also function through alternative mechanisms such as Jun activating binding protein affecting its influence on p27 kip1 [ref

(195) constructed HS-CAR-T cells incorporating a 7HE heat shock promoter, which restricts CAR expression and activation to heated areas/time periods, thereby reducing off-target toxicity and potentially preventing T cell exhaustion

Additionally, signaling pathways such as PI3K/Akt/mTOR and metabolites like succinate can also regulate the expression and stability of HIF-1 (71, 72)