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These amino acids also participate in signal transmission as neurotransmitters, and any change leading to an imbalance in neurotransmitters could alter the metabolic pathways in the brain, potentially leading to diseases of the central nervous system

In addition, regulatory T cells (Treg cells) and M2 macrophage fractions were significantly higher in poor response group while the fraction of activated NK cells and CD4 cells were substantially higher in disease control group

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Despite these promising effects in DN, the underlying molecular mechanisms and specific pharmacological targets remain poorly elucidated