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doi: 10.1016/j.bpj.2022.08.037 90 TsvetkovP.CoyS.PetrovaB.DreishpoonM.VermaA.AbdusamadM.et al

Due to the small size and high surface area to volume ratio (SVR) of the NPs, they could easily cross the biological hurdles, like the blood-brain barrier (BBB) (20, 21)