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Like NAD+, Glutathione production can naturally decline with age, as well as chronic stress, pollution exposure and poor diet

Medved I, Brown MJ, Bjorksten AR, Murphy KT, Petersen AC, Sostaric S, Gong X, McKenna MJ

When compared to euthyroid rats, in hyperthyroid rats, a two-fold increase in the activity of pyruvate kinase, which catalyses the synthesis of oxaloacetate from pyruvate, was observed (34)