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For example, studies from our lab and others show that alcohol increases HBV DNA and viral protein levels, correlating with higher ALT/AST and liver injury ( A key mechanism underlying this effect is that alcohol enhances HBV replication by stimulating the activity of the viral core and surface promoters

Crosstalk through NLRP3 The NLRP3 inflammasome is a multi-protein complex that recognizes PAMPs or damage-related molecular patterns (DAMPs) and activates the protease caspase-1, leading to pyroptosis and the formation of mature IL-1 and IL-18 to mediate the inflammatory response (151)

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Welsh DJ, Peacock AJ