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The protein nitration and inactivation of creatine kinase during heart failure in cardiac muscles are performed by peroxynitrites [77]

PF may exert antidepressant activity through a variety of mechanisms, such as preventing the overactivity of the HPA axis, regulating the monoaminergic nervous system, maintaining normal calcium homeostasis and calcium signaling pathway, inhibiting oxidative stress and apoptosis, and regulating the expression of neurotrophic factors in the brain (Figure 6)