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Busi shares, Realistically, once the damage is done and skin is experiencing Exogenous Ochronosis (where it starts turning a darker shade), it is challenging to restore the skin to its original condition, and there may be limits as to what can be achieved in clinic and expectations have to be managed. So, it is fair to say that the idea of skin bleaching and skin lightening will always remain a sensitive and controversial topic

The high number and location combined with their function render them important for the regulation of BBB function [18]