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Further research revealed that Parkin is recruited to damaged mitochondria through the action of phosphatase and tensin homolog-induced putative kinase 1 (PINK1), initiating the mitophagy process (Kawajiri et al., 2010

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Notably, it has been reported that the upregulation of HSP70 is closely linked to cuproptosis, and HSP70 is a crucial factor in activating innate immune response and aggravating the pathological changes in vitiligo (60, 61)