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One would expect that de novo B-cell responses require time to produce potent nAbs through some degree of affinity maturation, and hCoV-specific MBC responses have been considered a source of such rapidly emerging nAbs

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Kumar PA, Hu Y, Yamamoto Y, et al

J Appl Crystallogr 40:658674 McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A et al (2017) Characterization of three druggable hot-spots in the Aurora-A/TPX2 interaction using biochemical, biophysical, and fragment-based approaches