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GSTs conjugate 4HNE to GSH, and the corresponding glutathionyl-4-HNE (GS-HNE) is actively transported out of cells via RLIP76, a multifunctional membrane transporter for GSH-conjugated compounds, and/or MRPs (multidrug-resistance proteins

Furthermore, in IC metabolism, the methionine cycle is a major methyl donor, which is required for protein and nucleic acid methylation

For instance, engineered zinc-based nanoparticles such as zinc ferrite cores conjugated with disease-targeting moieties have been investigated for their ability to selectively deliver zinc into inflamed or dysfunctional cells, triggering organelle-specific responses