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Furthermore, long-term studies with extended observation periods, doseresponse profiling, and pharmacokinetic evaluation will be necessary to establish optimal dosing regimens and assess clinical safety

For example, two post mortem studies reported lower GSH in temporal and cerebellar regions in ASD [8,9], therefore GSH differences in ASD may well be brain-region specific

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As a result, RBC from G6PD deficient donors favor energy metabolism over antioxidant pathways, which protects them from morphological changes but makes them more susceptible to oxidant insults upon storage