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Alpha-GPC also increased striatal dopamine levels, likely by increasing acetylcholine availability.[ref][ref] Both CDP-choline (citicoline) and Alpha-GPC increase acetylcholine transporters and acetylcholine synthesis in the brain.[ref] Should You Worry About TMAO from Choline? I mentioned above that the drawback to higher choline intake is the creation of TMAO

One of the most critical interventions in this formula is the inclusion of Metafolin , a patented, naturally occurring form of L-5-methyltetrahydrofolate (L-5-MTHF)

Comprehensive plasma metabolomics studies of ME/CFS patients have identified significant dysregulation in lipid and energy metabolism, notably revealing decreased levels of circulating carnitine and choline

It can also be produced by chemical synthesis