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Tirzepatide: A review in type 2 diabetes

A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]

doi:10.3389/fphar.2022.1026182

But for researchers working with particularly sensitive peptides or planning extended storage, consulting the literature on optimal pH for your specific compound can yield meaningful stability improvements