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Extracellular Cu 2+ binding to ceruloplasmin is reduced by the metalloreductase six-transmembrane epithelial antigen of the prostate (SETAP) to Cu + , and copper transporter 1 (CTR1) (also known as solute carrier family 31 member 1, SLC31A1) transports Cu + into cells (Ohgami et al., 2006)

however, the genetic deletion of essential metabolic enzymes such as hexokinase-2, phosphoenolpyruvate kinase, and glutamate dehydrogenase does not markedly affect the architecture of the small intestine 21

Phototherapy using a fluoroquinolone antibiotic drug to suppress tumor migration and proliferation and to enhance apoptosis

10.1038/s41418-017-0012-4 50 GalluzziL.VitaleI.AbramsJ