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While these are animal studies, they suggest that GHK-Cu may have broad neurological effects that contribute to overall wellbeing during the sometimes emotionally turbulent post-weight-loss period

A: Use of POLYBION INJECTION is recommended when prescribed by a doctor or veterinarian, usually in cases of documented or suspected vitamin B-complex deficiency, after illness, surgery, or during recovery, and in stress-related nutritional depletion

This represents a significant gap between regulatory approval for safety (as a food substance) and clinical efficacy (which is absent or insufficient for weight loss)

There is around a 2.5-fold increase in B12 deficiency incidence in those treated with metformin, and this may occur as early as 3 months, although hepatic stores of vitamin B12 may take 5 years or more to deplete (Bell, 2022)