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Heffernan, Jiang, Thorburn, and Ng reported in the American Journal of Physiology that oral administration of AOD9401 to ob/ob mice was associated with reduced body-weight gain, altered adipose lipogenic and lipolytic activity, and acute changes in energy expenditure, evidence that a growth-hormone C-terminal fragment could act after oral delivery in a rodent model [3]

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doi:10.1021/es025834r Togola A, Budzinski H (2008) Multi-residue analysis of pharmaceutical compounds in aqueous samples

Instead of chemists making educated guesses about which modifications might improve oral bioavailability, algorithms can suggest the most promising changes based on vast databases of structure-activity relationships