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Elevated levels of ROS can be induced by excessive free iron or LIP through the Haber-Weiss and Fenton reactions, with ROS originating from various sources, including xanthine oxidase, NADPH oxidase, and mitochondria [60,61,62]

During the treatment, no significant change in the body weight of the mice was observed, indicating that NP4 has a high biocompatibility (Supplementary Fig

Corbin, [email protected] These authors have contributed equally to this work This article was submitted to Cancer Imaging and Image-directed Interventions, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

BME- and PureCol EZ Gel-based 2D organoid culturing Transwell inserts (Thincerts, 12-well, pore size 0.4 m, Greiner Bio-One 665641) were coated overnight with 2% dilutions of BME (ref