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10.1016/j.neuropharm.2017.05.014 Neuropharmacology 56 MalenkaR

It is essential for the formation and maintenance of myelin, the protective sheath that surrounds nerve fibers

Lipodystrophy manifests as abnormal fat distribution, marked by diminished fat in the face and limbs and increased abdominal and visceral fat, often as a side effect of antiretroviral medication