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doi: 10.1111/pbi.12112

COMT breaks down: Dopamine Norepinephrine Epinephrine (adrenaline) Estrogen (specifically catechol estrogens) Catechols from diet This means COMT is deeply connected to: Mood, motivation, and emotional stability (dopamine) Stress response and recovery (norepinephrine, epinephrine) Hormone balance and reproductive health (estrogen) Pain perception and sensitivity (dopamine and norepinephrine modulate pain pathways) Cognitive function and working memory (prefrontal cortex dopamine levels) When COMT is dirty: Fast COMT: Too little dopamine, norepinephrine in the synapse = low motivation, poor focus, flat mood, need for stimulation

The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimers disease

Although Wilsons disease always begins with liver involvement, many patients may be asymptomatic and therefore go undiagnosed until they present at 2030 years of age with advanced hepatic or neurologic disease