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First, the pulmonary abnormalities (e.g., haemorrhage and congestion) of the mice treated with MTX for a week or 2 weeks were investigated after thoracotomy under anaesthesia

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The surplus of ROS represents a trigger for programmed cell death processes and promotes the release of pro-inflammatory cytokines, which are also responsible for further increasing ROS levels, thus perpetuating the pathophysiological process of AD