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It is unknown whether ROS exert their effects at the transcriptional levels by directly activating certain redox-sensitive transcriptional factors (TF) or, indirectly, by promoting the release of cytokines as part of the inflammatory response secondary to the oxidative tissue injury which may, in turn, activate a different set of TFs

Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the Male offspring rats

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This clearance process happens in the liver through a two-step metabolic pathway