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doi:10.1007/s11095-016-1941-1 [27] Long J

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By secreting Il-1, TNF and complement component subunit 1q, the activated microglia induce the formation of neurotoxic reactive astrocytes which lose the ability to support neuronal survival, outgrowth, synaptogenesis and phagocytosis, leading to the death of neurons and oligodendrocytes (Zhang L

Results Monocyte-derived macrophages from Crohns disease display increased sensitivity to H 2 O 2 induced ferroptosis When retrieving macrophages from plastic culture dishes through trypsinization we see a decreased recovery of macrophages from patients with active CD compared to healthy controls (Table 1)