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The critical role of NAD + pool in tumorigenesis NAD + not only acts as a co-enzyme for metabolic redox reactions, but also functions as a co-substrate to modulate the activity of NAD + -consuming enzymes that govern the critical steps in tumorigenesis, including genome stability, metabolism, cell growth, cell death, redox homeostasis and immune response

(2) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 g/kg), l-NAME (10 mg/kg) and l-arginine (30 mg/kg) were applied alone and/or combined