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doi: 10.1261/rna.2214510 84 EsauC.DavisS.MurrayS

(2012) found miR-181c , Ago2, and COX1 in mitochondrial co-immunoprecipitate, suggesting that mature miR-181c could translocate to mitochondria and together with Ago2 repress the translation of this mitochondrial transcript

Collectively, these interventions sustain neuronal bioenergetics by preserving TCA cycle flux, enhancing MRC function, and stabilizing ATP homeostasis, thereby preventing energy depletion