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hepcidin also downregulates its synthesis through a negative feedback loop depending on circulating iron concentration to prevent iron overload in the body (Yao and Li, 2023)

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doi: 10.1186/s12951-024-02648-5 148

However, upon release in the hydrophilic cytoplasm, the fluorescence of the dye is quenched, allowing for the facile detection of the degradation of the nanoparticles