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doi: 10.1016/j.metabol.2020.154188 50 HussainMASchmitzOMengelAGlatzYChristiansenJSZapfJet al

IGF-I signaling in skeletal cell-cell interactions In addition to their interactions through hormonal factors, like osteoblastic M-CSF, which activates c-fms in osteoclasts, osteoblasts, osteoclasts and chondrocytes, can also communicate with each other through physical interactions using their cell-surface ligands and receptors