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Additionally, urolithins can regulate cholesterol metabolism by reducing the abundance of Coriobacteriaceae bacteria and altering the bile acid pool, thereby promoting lipid absorption in the intestines and providing cardiovascular protection ( FIGURE 2 Upon entering the human body, ellagitannins undergo bidirectional modulation with the gut microbiota

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PERK activation enables tumor cells to transiently attenuate global protein synthesis while selectively enhancing the translation of stress-responsive genes that promote survival, invasion, and metabolic rewiring