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PLCs are classically coupled to GPCRs, therefore we tested orphan GPCR Olfr39 overexpressing cells identified in the same screen [32] and observed the prototypical pattern of Ms4a15 OE in viability, Ca 2+ , and lipid regulation (Supplementary Fig

Additionally, studies show that GPX4 inactivation induces hippocampal neuron death, while alpha-lipoic acid protects neurons by regulating GPX4 expression (Zhang YH

184 Astrocytic reactivity in diffuse brain injury is quite distinct from full blown reactive astrogliosis in focal TBI

Recently, an increasing number of studies have demonstrated the important regulatory role played by epigenetic mechanisms, especially DNA, RNA, and protein methylation, in ferroptosis