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Each type performs differently in pH-sensitive cleavable linker design, and selection must consider payload properties, plasma stability, and release kinetics

When a frameshift mutation replaces the IDR acidic tail of HMGB1 with an arginine-rich basic tail, HMGB1 with a mutant tail undergoes LLPS to form droplets at a lower concentration, attenuates the dynamic and liquid fluidity of HMGB1 droplets, and facilitates HMGB1 partitioning into nuclear condensates, culminating in mispartitioning into the nucleolus

10.1093/cvr/cvu050 325 ZhangX.ZhuJ.-X.MaZ.-G.WuH.-M.XuS.-C.SongP.et al (2019)

In the case of UC, mature dendritic cells become more sensitive and activated, indicating their significant involvement in generating inflammation [46]