They received 50, 150, or 300 mg canakinumab, or placebo as subcutaneous injections every three months for a median of 3.7 years
Access this article Similar content being viewed by others Abbreviations 5-HT: 5-hydroxytryptamine or serotonin ACTH: corticotropin AGRP: agouti gene-related protein CART: cocaine- and amphetamine-regulated transcript CCK: cholecystokinin CGRP: calcitonin gene-related peptide CNS: central nervous system CRH: corticotropin-releasing hormone DRG: dorsal root ganglion DSIP: delta sleep-inducing peptide GABA: -amino-butyric acid GLP-1: glucagon-like peptide 1 GPCR: G-protein-coupled receptor IAPP: islet amyloid polypeptide LGV: large granular vesicle LHRH: luteinizing hormone-releasing hormone -MSH: -melanocyte-stimulating hormone NO: nitric oxide NPY: neuropeptide tyrosine PACAP: pituitary adenylyl cyclase-activating peptide PHI: peptide histidine isoleucine PP: pancreatic polypeptide PCR: polymerase chain reaction PNS: peripheral nervous system PYY: peptide tyrosine tyrosine SP: substance P SSV: small synaptic vesicle TGN: trans-Golgi network TRH: thyrotropin-releasing hormone VIP: vasoactive intestinal polypeptide References Agnati LF, Fuxe K, Benfenati F, Battistini N, Harfstrand A, Hkfelt T, Cavicchioli L, Tatemoto K, Mutt V (1983) Failure of neuropeptide Y in vitro to increase the number of alpha 2-adrenergic binding sites in membranes of medulla oblongata of the spontaneous hypertensive rat
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