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For instance, fecal microbiota from patients with BD can induce neutrophil activation when transferred to mice, which contributes to the differentiation of pathogenic T cells (65)

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It is worth noting that superoxide production is partially restored in Rac2 / PMNs previously primed with certain stimuli, such as TNF- or elicited by thioglycollate, suggesting that Rac1 might be sufficient to activate the NADPH oxidase in primed PMNs (Roberts et al., 1999)