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Suresh Ramalingam, executive director of Winship Cancer Institute of Emory University and the trials principal investigator, called the approval a major breakthrough for this patient group

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Glutamate-induced release of BDNF via mGluR-activation was observed within 10 min of stimulation, while kainate or NMDA application failed to induce release of BDNF in astrocytic cultures

That is why in your genetic raw data, you will see G for the typical and A for the variant, but many research studies will still include C for the typical and T for the variant